看见一个 Expert Review of Anticancer Therapy。你们前面用依维莫斯,血、肝肾功能还好。下一步是否考虑索拉非尼+依维莫斯。供你参考。; o: c9 h e8 v7 c# U, K- x
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Currently available feasibility data for possible combination strategies. : }$ H# Z; Y* V
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Combination Feasibility according to preliminary data
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; h' O# Z1 w! S( @: gBevacizumab + sorafenib Yes, reduced dose
8 S0 v! ]" @' y' D' p8 hBevacizumab + sunitinib† No
8 s; c0 J/ g& X/ F" ` w) [# m bBevacizumab + temsirolimus Yes
2 k" S, v% x3 A- XBevacizumab + everolimus Yes 3 N/ u0 m8 ~1 T2 F o3 h& s
Sorafenib + sunitinib ?
$ R1 z9 b% |+ y( C# I9 z5 aSorafenib + temsirolimus Yes, reduced dose ; G. ?( ^( U( I2 i. B" c
Sorafenib + everolimus Yes, reduced dose & y! Q8 R! P( p( m e7 `% |
Sunitinib + temsirolimus† No 5 ]* k: V* L, G, L' r" ?1 g
Sunitinib + everolimus ? 5 a! [* g" J3 `' c; [: H: Z
Temsirolimus + everolimus ? + Q( J4 O! a& @9 V1 |9 k
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†Led to US FDA warning.
R3 }, Y5 M. ]; ^7 Z, m6 \; Y3 q?: As yet unattempted combination.
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