看见一个 Expert Review of Anticancer Therapy。你们前面用依维莫斯,血、肝肾功能还好。下一步是否考虑索拉非尼+依维莫斯。供你参考。' ~1 I3 l$ m, @7 c" H. d
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Currently available feasibility data for possible combination strategies. 6 ^9 o, M! |* J2 ?' U- N
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Combination Feasibility according to preliminary data - V; _5 `& q2 F) I( F) F: A3 u
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Bevacizumab + sorafenib Yes, reduced dose
5 l0 C! l1 {! f( U' x. u0 E3 j& pBevacizumab + sunitinib† No
0 j5 |3 D3 S' j% r% K6 H9 }Bevacizumab + temsirolimus Yes
2 J; ?) L% y, _7 C) \+ uBevacizumab + everolimus Yes 9 n' ?. |* s5 i- B- o
Sorafenib + sunitinib ?
2 h4 ] d9 r" L, a" }Sorafenib + temsirolimus Yes, reduced dose 0 Z5 P @9 G u: g
Sorafenib + everolimus Yes, reduced dose
0 r4 W+ y+ L: a+ [. \1 R6 {Sunitinib + temsirolimus† No 5 n7 Y) P" M! O( [& g& ^
Sunitinib + everolimus ?
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†Led to US FDA warning.
4 W, I. _: m# w5 x1 s?: As yet unattempted combination.1 ]) N' ^" e" f" j' i3 ~
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