发给老马备查:( x! S, E" {5 Z% H
滴水察海(69304838) 15:23:23
7 `( H$ l" R6 J& R* w) n老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱" y7 S# i" h" S2 v/ P
吉非替尼和S-1连用的依据; S/ J) v& x% U3 D
Gefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.
" t8 ]" X8 G- k5 Z7 ?. R是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达
0 _% V) v7 S7 d: {1 b这样是不是推理出,耐药后,可以用S-1和培美了?2 U' Q% x9 t2 p0 X8 ~
结论:9 k* b. I0 e6 n( S- d7 |2 k
如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |