发给老马备查:: M# x' L4 O3 j1 s. [
滴水察海(69304838) 15:23:23
/ w: ]: J1 C! T( X9 A9 X老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱( A2 @2 P& [4 F
吉非替尼和S-1连用的依据; U0 H5 i8 o/ M& O1 x
Gefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.
5 @: q& u j- I/ P! ?. P: ]$ h. h! w是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达, X) x, y5 `" P4 J0 H2 u9 N' P/ V
这样是不是推理出,耐药后,可以用S-1和培美了?" l5 V, M1 i7 g7 {# @* i, l5 f
结论:
, r! w4 m7 k! r J( N) d; H如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |