发给老马备查:
$ s7 }8 K2 P$ Q2 Q% {' i9 n7 v滴水察海(69304838) 15:23:23. v% M9 J; u* D. T$ U- Q
老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱
- B3 f* h. |. a% b7 e# M6 V吉非替尼和S-1连用的依据
" y. I* ^+ P" S- z1 N: u& M) J! n- aGefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.' Y! [5 N, A4 o/ O6 L! W0 j
是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达1 o$ R5 S$ d$ d5 }
这样是不是推理出,耐药后,可以用S-1和培美了?) y* G/ Z# g+ D& ~7 W: h
结论:
% S; k! k: N# W7 Z/ n) a% q0 B. K如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |